Issue 3, 2023

A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

Abstract

Glutathione peroxidase 4 (GPX4) is overexpressed in non-small cell lung cancer (H1299) cells. In this work, a near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that ENBO-ML210 could target and visualize GPX4 in H1299 cells, exhibiting potential for the diagnosis of non-small lung cancer.

Graphical abstract: A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2022
Accepted
01 Dec 2022
First published
02 Dec 2022

Chem. Commun., 2023,59, 294-297

A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging

Q. Hu, W. Zhu, J. Du, S. Long, W. Sun, J. Fan and X. Peng, Chem. Commun., 2023, 59, 294 DOI: 10.1039/D2CC06161A

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