Issue 6, 2023

Small-molecule photoswitches for fluorescence bioimaging: engineering and applications

Abstract

Fluorescence microscopy has revolutionised our understanding of biological systems, enabling the visualisation of biomolecular structures and dynamics in complex systems. The possibility to reversibly control the optical or biochemical properties of fluorophores can unlock advanced applications ranging from super-resolution microscopy to the design of multi-stimuli responsive and functional biosensors. In this Highlight, we review recent progress in small-molecule photoswitches applied to biological imaging with an emphasis on molecular engineering strategies and promising applications, while underlining the main challenges in their design and implementation.

Graphical abstract: Small-molecule photoswitches for fluorescence bioimaging: engineering and applications

Article information

Article type
Highlight
Submitted
28 Oct 2022
Accepted
29 Nov 2022
First published
09 Jan 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 660-669

Small-molecule photoswitches for fluorescence bioimaging: engineering and applications

M. Olesińska-Mönch and C. Deo, Chem. Commun., 2023, 59, 660 DOI: 10.1039/D2CC05870G

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