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Recognition of electroneutral Lewis bases and anions in aqueous media is extremely difficult. We show that fluorescent coordinatively unsaturated metal complexes can recognize various Lewis bases while providing an easy-to-detect fluorescence response. This approach is applied to the detection of adrafinil, a banned performance-enhancing drug.

Graphical abstract: Fluorescent zinc and copper complexes for detection of adrafinil in paper-based microfluidic devices

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