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Issue 14, 2015
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Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging

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Abstract

Gold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching and a careful design must be carried out to maintain optoelectronic properties and biocompatibility. In this work, the synthesis of fluorescent gold nanoprobes, able to enter the cell's environment (biotags) and target the cell nucleus, was designed and the particles tracked by confocal laser scanning microscopy. The coating of AuNPs with maleimide poly(ethylene glycol) and fluorescent oligoaziridine biocompatible oligomers, resulted in robust, optically active biotags that open novel insights into cancer theragnosis.

Graphical abstract: Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging

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Publication details

The article was received on 03 Dec 2014, accepted on 07 Jan 2015 and first published on 07 Jan 2015


Article type: Paper
DOI: 10.1039/C4RA15743E
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Citation: RSC Adv., 2015,5, 10733-10738

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    Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging

    A. S. Silva, V. D. B. Bonifácio, V. P. Raje, P. S. Branco, P. F. B. Machado, I. J. Correia and A. Aguiar-Ricardo, RSC Adv., 2015, 5, 10733
    DOI: 10.1039/C4RA15743E

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