Jump to main content
Jump to site search

Issue 38, 2015
Previous Article Next Article

Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Author affiliations

Abstract

Three new 10-membered macrolides, saccharothriolides A–C (1–3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

Graphical abstract: Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Mar 2015, accepted on 31 Mar 2015 and first published on 01 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC01953B
Citation: Chem. Commun., 2015,51, 8074-8077
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

    S. Lu, S. Nishimura, G. Hirai, M. Ito, T. Kawahara, M. Izumikawa, M. Sodeoka, K. Shin-ya, T. Tsuchida and H. Kakeya, Chem. Commun., 2015, 51, 8074
    DOI: 10.1039/C5CC01953B

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements