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Issue 22, 2002
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Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins

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Abstract

Deuterated (−)-Δ9-tetrahydrocannabivarins (Δ9-THCVs) can be used as markers for confirming the illicit use of marijuana. Here, we first describe an efficient synthesis of side chain deuterated Δ9-THCVs from the respective 5-propylresorcinols specifically deuterated at the side chain. Our approach involved the development of optimal, high yield methods for the introduction of deuterium at the C-3′ and C-2′ position of the side chain.

Graphical abstract: Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins

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Publication details

The article was received on 06 Jun 2002, accepted on 24 Sep 2002 and first published on 24 Oct 2002


Article type: Paper
DOI: 10.1039/B205459K
J. Chem. Soc., Perkin Trans. 1, 2002, 2544-2548

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    Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins

    S. P. Nikas, G. A. Thakur and A. Makriyannis, J. Chem. Soc., Perkin Trans. 1, 2002, 2544
    DOI: 10.1039/B205459K

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