Issue 27, 2023

Three-component synthesis of N-naphthyl pyrazoles via Rh(iii)-catalyzed cascade pyrazole annulation and Satoh–Miura benzannulation

Abstract

The synthesis of N-naphthyl pyrazoles has been realized by the direct three-component reactions of enaminones, aryl hydrazine hydrochlorides and internal alkynes via Rh(III) catalysis. The synthetic reactions employing simple substrates lead to simultaneous construction of dual cyclic moieties, including a pyrazole ring and a phenyl ring, via sequential formation of two C–N and three C–C bonds.

Graphical abstract: Three-component synthesis of N-naphthyl pyrazoles via Rh(iii)-catalyzed cascade pyrazole annulation and Satoh–Miura benzannulation

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2023
Accepted
09 Mar 2023
First published
09 Mar 2023

Chem. Commun., 2023,59, 4036-4039

Three-component synthesis of N-naphthyl pyrazoles via Rh(III)-catalyzed cascade pyrazole annulation and Satoh–Miura benzannulation

D. Chen, L. Zhou, Y. Liu and J. Wan, Chem. Commun., 2023, 59, 4036 DOI: 10.1039/D3CC00649B

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