Issue 29, 2023

Convergent synthesis of triarylamines via Ni-catalyzed dual C(sp2)–H amination from benzamides with benzohydroxamic acids

Abstract

An unprecedented method of nickel-catalyzed dual C(sp2)–H amination of N-quinolylbenzamides with benzohydroxamic acids is developed to access triarylamines in one pot. For the first time, broad-spectrum hydroxylamine is employed as an amino source for C–H amination, featuring good chemo-selectivity and functional group tolerance. Furthermore, the catalytic system could be further extended to N-(pivaloyloxy)benzamide, dioxazolone, isocyanate and aniline for C–H amination.

Graphical abstract: Convergent synthesis of triarylamines via Ni-catalyzed dual C(sp2)–H amination from benzamides with benzohydroxamic acids

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2023
Accepted
15 Mar 2023
First published
15 Mar 2023

Chem. Commun., 2023,59, 4360-4363

Convergent synthesis of triarylamines via Ni-catalyzed dual C(sp2)–H amination from benzamides with benzohydroxamic acids

W. Li, R. Wang, Z. Li, J. Chen, Y. Zhang and N. Lv, Chem. Commun., 2023, 59, 4360 DOI: 10.1039/D3CC00165B

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