Issue 25, 2024

Nanomaterials promote the fast development of electrochemical MiRNA biosensors

Abstract

Cancer has become the leading cause of death worldwide. In recent years, molecular diagnosis has demonstrated great potential in the prediction and diagnosis of cancer. MicroRNAs (miRNAs) are short oligonucleotides that regulate gene expression and cell function and are considered ideal biomarkers for cancer detection, diagnosis, and patient prognosis. Therefore, the specific and sensitive detection of ultra-low quantities of miRNA is of great significance. MiRNA biosensors based on electrochemical technology have advantages of high sensitivity, low cost and fast response. Nanomaterials show great potential in miRNA electrochemical detection and promote the rapid development of electrochemical miRNA biosensors. Some methods and signal amplification strategies for miRNA detection in recent years are reviewed herein, followed by a discussion of the latest progress in electrochemical miRNA detection based on different types of nanomaterial. Future perspectives and challenges are also proposed for further exploration of nanomaterials to bring breakthroughs in electrochemical miRNA detection.

Graphical abstract: Nanomaterials promote the fast development of electrochemical MiRNA biosensors

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Article information

Article type
Review Article
Submitted
04 Dec 2023
Accepted
18 May 2024
First published
04 Jun 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 17929-17944

Nanomaterials promote the fast development of electrochemical MiRNA biosensors

R. Ouyang, Y. Huang, Y. Ma, M. Feng, X. Liu, C. Geng, Y. Zhao, S. Zhou, B. Liu and Y. Miao, RSC Adv., 2024, 14, 17929 DOI: 10.1039/D3RA08258J

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