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Issue 16, 2017
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Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

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Abstract

Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.

Graphical abstract: Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

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Article information


Submitted
24 Dec 2016
Accepted
30 Jan 2017
First published
08 Feb 2017

This article is Open Access

Chem. Commun., 2017,53, 2451-2454
Article type
Communication

Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy

N. Kumar, M. M. Drozdz, H. Jiang, D. M. Santos and D. J. Vaux, Chem. Commun., 2017, 53, 2451
DOI: 10.1039/C6CC10226C

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