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Issue 41, 2013
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π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery

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Abstract

Molecular targeted delivery of therapeutic agents and their stimuli-responsive release are some of the major issues for modern medical administration, particularly in cancer chemotherapy. In this study, we developed a π-hyaluronan nanocarrier (πHNC) for CD44-targeted and pH-boosted delivery of an aromatic anticancer drug to cancer cells. Amphiphilic π-hyaluronan (pyrenyl hyaluronan, πHA) was synthesized using EDC chemistry, and self-assembled to form πHNC, the structure of which was obviously micellar but was convincingly effective to function; (i) a π-rich pyrenyl core of πHNC, a loading aromatic drug (doxorubicin, DOX) by π-stacking attraction, showed a rapid release profile under low pH conditions which is a notable characteristic of the cancer microenvironment as well as the endolysosomal state after uptake into the target cell and (ii) the hydrophilic hyaluronan shell of πHNC acted as a ligand for CD44 resulting in the localization of πHNC into the target cell by CD44-mediated endocytosis, without cytotoxicity. With its targeted and stimulated delivery of aromatic drugs to the target cells, DOX-loaded πHNC (πHNC/DOX) provided effectual therapeutic activity in both in vitro and in vivo models of CD44-positive human gastric cancer, which is suitable as a facile and efficient drug delivery platform.

Graphical abstract: π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery

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Publication details

The article was received on 27 Jun 2013, accepted on 19 Aug 2013 and first published on 18 Sep 2013


Article type: Paper
DOI: 10.1039/C3TB20906G
J. Mater. Chem. B, 2013,1, 5686-5693

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    π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery

    E. Jang, E. Lim, Y. Choi, E. Kim, H. Kim, D. Kim, J. Suh, Y. Huh and S. Haam, J. Mater. Chem. B, 2013, 1, 5686
    DOI: 10.1039/C3TB20906G

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