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Issue 6, 2013
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Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and ureahydrogen peroxide as oxidants

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Abstract

By integrating a heterogeneous oxidation step, gas–liquid separation, and an oxidative amidation reaction to form a continuous system, a multistep synthetic protocol has been demonstrated to produce amides under mild conditions using alcohols and amines as the starting materials. The use of inexpensive oxygen and urea hydrogen peroxide as the only oxidants affords an economical and adaptable synthetic route for amides.

Graphical abstract: Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants

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Supplementary files

Article information


Submitted
27 Feb 2013
Accepted
28 Mar 2013
First published
02 Apr 2013

Green Chem., 2013,15, 1538-1541
Article type
Paper

Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants

X. Liu and K. F. Jensen, Green Chem., 2013, 15, 1538
DOI: 10.1039/C3GC40407B

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