Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 8, 2014
Previous Article Next Article

Interaction of oxovanadium(iv)–salphen complexes with bovine serum albumin and their cytotoxicity against cancer

Author affiliations

Abstract

Vanadyl compounds of clinical significance are recommended as drugs against diseases such as tuberculosis, diabetes, cancer, etc. In order to check the potential of the salphen ligands and oxovanadium(IV)–salphen complexes as drugs their binding with bovine serum albumin (BSA) is investigated. The binding constants measured at pH 7.4 using UV-vis absorption and fluorescence techniques are in the range of 103–105 M−1. The quenching of the fluorescence of BSA and appearance of enhanced luminescence of the salphen ligand/vanadium(IV) complex at the increased [quencher] show efficient FRET from the protein to the quencher and the distance of energy transfer estimated using Forster's theory is in the range of 1.4–3.5 nm. Molecular docking studies (DFT) utilizing oxovanadium(IV)–salphen derivatives show strong binding with BSA and give insight into the binding modes, interaction pattern and stability of synthesized complexes in the target site. The cytotoxicity study shows the ability of these V(IV) complexes to inhibit the growth of AGS gastric cell lines.

Graphical abstract: Interaction of oxovanadium(iv)–salphen complexes with bovine serum albumin and their cytotoxicity against cancer

Back to tab navigation

Supplementary files

Article information


Submitted
12 Sep 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Dalton Trans., 2014,43, 3260-3272
Article type
Paper
Author version available

Interaction of oxovanadium(IV)–salphen complexes with bovine serum albumin and their cytotoxicity against cancer

V. Gomathi Sankareswari, D. Vinod, A. Mahalakshmi, M. Alamelu, G. Kumaresan, R. Ramaraj and S. Rajagopal, Dalton Trans., 2014, 43, 3260
DOI: 10.1039/C3DT52505H

Social activity

Search articles by author

Spotlight

Advertisements