Issue 42, 2023

A tetranuclear Mn-diamond core complex as a functional mimic of both catechol oxidase and phenoxazinone synthase enzymes

Abstract

Through dioxygen activation, a tetranuclear Mn(II,III,III,II) diamond core, [Mn4(HPTP*)2(μ-O)2(H2O)4](ClO4)4 (1) complex, has been synthesised using a suitably designed septadentate ligand framework (HPTP*H = 1,3-bis(bis((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)amino)propan-2-ol). The newly prepared complex 1 was characterised using multiple spectroscopic techniques and X-ray crystallography. 1 exhibits excellent catalytic oxidation reactivity for the model substrates, namely, 3,5-di-tert-butylcatechol (3,5-DTBC) and 2-aminophenol, efficiently mimicking the enzymes catechol oxidase and phenoxazinone synthase, respectively. Remarkably, we employed aerial oxygen to catalyze the oxidation of these model substrates, 3,5-DTBC and 2-aminophenol, with turnover numbers of 835 and 14, respectively. A tetranuclear Mn-diamond core complex that mimics both catechol oxidase and phenoxazinone synthase could pave the way for further research into its potential as a multi-enzymatic functional mimic.

Graphical abstract: A tetranuclear Mn-diamond core complex as a functional mimic of both catechol oxidase and phenoxazinone synthase enzymes

Supplementary files

Article information

Article type
Paper
Submitted
13 Mar 2023
Accepted
10 May 2023
First published
11 May 2023

Dalton Trans., 2023,52, 15412-15419

A tetranuclear Mn-diamond core complex as a functional mimic of both catechol oxidase and phenoxazinone synthase enzymes

R. Kumar, R. Keshri, K. Prodhan, K. Shaikh and A. Draksharapu, Dalton Trans., 2023, 52, 15412 DOI: 10.1039/D3DT00761H

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