Issue 27, 2016
From the journal:

Organic & Biomolecular Chemistry

Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity†

Zhi-Qin Liang,ab   Dong-Ling Wang,a   Chun-Lin Zhangab  and  Song Ye*ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: songye@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P.R. China

Abstract

The enantioselective N-heterocyclic carbene-catalyzed [2 + 4] cyclocondensation of α-chloroaldehydes and saccharine-derived 1-azadienes was developed, giving the corresponding saccharine-derived dihydropyridinones in good yields with exclusive cis-selectivities and excellent enantioselectivities.

Graphical abstract: Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity

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Article information

DOI
https://doi.org/10.1039/C6OB01040G
Article type
Communication
Submitted
13 May 2016
Accepted
10 Jun 2016
First published
10 Jun 2016

Org. Biomol. Chem., 2016,14, 6422-6425

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Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity

Z. Liang, D. Wang, C. Zhang and S. Ye, Org. Biomol. Chem., 2016, 14, 6422 DOI: 10.1039/C6OB01040G

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