Acylation of in situ generated trimethylsilyl diethylphosphonoacetate using magnesium chloride–triethylamine: a practical synthesis of β-keto phosphonates

Abstract

In situ generated trimethylsilyl diethylphosphonoacetate from diethyl phosphonoacetic acid can be acylated with carboxylic acid chlorides in the presence of magnesium chloride to prepare a variety of β-keto phosphonates. This synthetic method is suitable for the preparation of β-keto phosphonates in the laboratory and also for large-scale production.

References

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