Issue 12, 2024

Palladium-catalysed α and β C–H allylation of aryl alkenes

Abstract

Remarkable progress has been made on chelation-assisted α and β C–H functionalization of aryl alkenes; however, there is no report on C–H allylation reactions. This work focuses on the first α and β C–H allylation of aryl alkenes using allyl carbonates to produce linear and branched 1,4-dienes enabled by chelation-assistance of pyridine-2-carboxamide, simply performed with Pd(OAc)2/AcOH in ethanol. This operationally simple protocol exhibited wide functionality tolerance and broad substrate scope and enabled successful gram-scaled preparation.

Graphical abstract: Palladium-catalysed α and β C–H allylation of aryl alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
29 Jan 2024
Accepted
17 Apr 2024
First published
30 Apr 2024

Org. Chem. Front., 2024,11, 3341-3347

Palladium-catalysed α and β C–H allylation of aryl alkenes

Y. Liao, X. Zhang, X. Li, X. Liu, J. Chen, C. Shen, R. He, G. Zhong and J. Zhang, Org. Chem. Front., 2024, 11, 3341 DOI: 10.1039/D4QO00188E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements