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Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer


Krishnendu Pal, Farah Al-suraih, Roberto Gonzalez-Rodriguez, Shamit Kumar Dutta, Enfeng Wang, H. Shaun Kwak, Thomas R. Caulfield, Jeffery L. Coffer and Santanu Bhattacharya
Nanoscale, 2017,9, 15622-15634

Abstract

Tumor-selective uptake of plectin-1 targeting peptide-modified gold nanoparticles ameliorates targeted delivery of gemcitabine in pancreatic ductal adenocarcinoma.


Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model


Priyanka Gupta, Stella Totti, Pedro A. Pérez-Mancera, Eleanor Dyke, Andrew Nisbet, Giuseppe Schettino, Roger Webb and Eirini G. Velliou
RSC Adv., 2019,9, 41649-41663

Abstract

Poly-urethane scaffold based 3D pancreatic cancer model enables realistic long term chemotherapy and radiotherapy screening. This model can be used for personalised treatment screening.


A 3D bioinspired highly porous polymeric scaffolding system for in vitro simulation of pancreatic ductal adenocarcinoma


Stella Totti, Mark C. Allenby, Susana Brito Dos Santos, Athanasios Mantalaris and Eirini G. Velliou
RSC Adv., 2018,8, 20928-20940

Abstract

A 3D biomimetic model for in vitro studies of pancreatic cancer.


Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer


Vijay Sagar Madamsetty, Krishnendu Pal, Sandeep Keshavan, Thomas R. Caulfield, Shamit Kumar Dutta, Enfeng Wang, Bengt Fadeel and Debabrata Mukhopadhyay
Nanoscale, 2019,11, 22006-22018

Abstract

Schematic representation demonstrating the fabrication and in vivo evaluation of an immune-modulatory nano-formulation consisting of irinotecan and curcumin in immune-competent mouse models of pancreatic adenocarcinoma.


Predicting cancer cell invasion by single-cell physical phenotyping


Kendra D. Nyberg, Samuel L. Bruce, Angelyn V. Nguyen, Clara K. Chan, Navjot K. Gill, Tae-Hyung Kim, Erica K. Sloan and Amy C. Rowat
Integr. Biol., 2018,10, 218-231

Abstract

High throughput quantitative deformability cytometry (q-DC) is used to develop a predictive model of cancer cell invasion based on physical phenotypes.


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