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Issue 7, 2019
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A fluorogenic C4N4 probe for azide-based labelling

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Abstract

The design, synthesis and photophysical properties of a new fluorogenic probe are described. The structure is based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore. The strain-promoted [3 + 2] cycloaddition of the azido-C4N4 probe furnished a triazole that exhibited more than 30-fold enhancement in fluorescence intensity as compared to the azide.

Graphical abstract: A fluorogenic C4N4 probe for azide-based labelling

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Publication details

The article was received on 31 Oct 2018, accepted on 04 Dec 2018 and first published on 11 Dec 2018


Article type: Communication
DOI: 10.1039/C8OB02695E
Citation: Org. Biomol. Chem., 2019,17, 1813-1816

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    A fluorogenic C4N4 probe for azide-based labelling

    H. Noda, Y. Asada, M. Shibasaki and N. Kumagai, Org. Biomol. Chem., 2019, 17, 1813
    DOI: 10.1039/C8OB02695E

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