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Issue 13, 2017
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Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering

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Abstract

We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and proliferation of neonatal cardiomyocytes. Furthermore, composites containing nanosilver prevented biofilm formation but did not activate macrophages.

Graphical abstract: Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering

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Article information


Submitted
09 Feb 2017
Accepted
14 Mar 2017
First published
15 Mar 2017

J. Mater. Chem. B, 2017,5, 2402-2406
Article type
Communication

Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering

S. Allison, M. Ahumada, C. Andronic, B. McNeill, F. Variola, M. Griffith, M. Ruel, V. Hamel, W. Liang, E. J. Suuronen and E. I. Alarcon, J. Mater. Chem. B, 2017, 5, 2402
DOI: 10.1039/C7TB00405B

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