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Issue 9, 2017
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Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

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Abstract

The photocytotoxic activity of porphyrin-containing materials including metal–organic frameworks (MOFs) has attracted ever increasing interest. We have developed a simple synthesis of hexagonal PCN-222/MOF-545 nanoparticles, which are powerful in inducing reactive oxygen species-mediated apoptosis of cancer cells upon visible light irradiation. The extent of the cytotoxic effect well correlates with the nanoparticle size and structural instability. High phototoxicity of the presented nanoparticles and their deactivation within several hours open up the door to possible applications in cancer therapy.

Graphical abstract: Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

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Supplementary files

Article information


Submitted
13 Dec 2016
Accepted
31 Jan 2017
First published
31 Jan 2017

J. Mater. Chem. B, 2017,5, 1815-1821
Article type
Paper

Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

D. Bůžek, J. Zelenka, P. Ulbrich, T. Ruml, I. Křížová, J. Lang, P. Kubát, J. Demel, K. Kirakci and K. Lang, J. Mater. Chem. B, 2017, 5, 1815
DOI: 10.1039/C6TB03230C

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