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Issue 14, 2017, Issue in Progress
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Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines

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Abstract

An efficient route for the synthesis of penta-substituted/functionalized-3,4-diarylated pyridines, biologically important templates, via pyridine C3-arylation of nicotinic acids has been developed. The poly-substituted nicotinic acid precursors were prepared by an established multicomponent condensation approach. This route shows an excellent opportunity for introducing versatile (hetero)aryls and other substituents/functionalities into the pyridine ring. Several of the synthesized compounds exhibited significant anti-proliferative properties.

Graphical abstract: Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines

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Publication details

The article was received on 16 Dec 2016, accepted on 18 Jan 2017 and first published on 25 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA28299G
RSC Adv., 2017,7, 8323-8331
  • Open access: Creative Commons BY-NC license
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    Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines

    S. K. Guchhait, N. Hura, K. Sinha and D. Panda, RSC Adv., 2017, 7, 8323
    DOI: 10.1039/C6RA28299G

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