Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 7, 2017
Previous Article Next Article

Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Author affiliations

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand–protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

Graphical abstract: Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Back to tab navigation

Supplementary files

Article information


Submitted
07 Nov 2016
Accepted
18 Jan 2017
First published
24 Jan 2017

Org. Biomol. Chem., 2017,15, 1570-1574
Article type
Communication

Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

A. R. Patel, A. Hardianto, S. Ranganathan and F. Liu, Org. Biomol. Chem., 2017, 15, 1570
DOI: 10.1039/C7OB00129K

Social activity

Search articles by author

Spotlight

Advertisements