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Issue 2, 2017
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Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model

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Abstract

The purple yam, Dioscorea alata L., is an important source of starch, vitamins and polyphenols. Five different pigments from the purple tubers of this plant were separated by high-performance liquid chromatography–mass spectrometry, and the anthocyanin fraction (DACN) was collected. The anti-inflammatory effects of DACNs were investigated at different concentrations and compared with the standard colitis treatment, 5-aminosalicylic acid, in a trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model. Macro- and microscopic parameters including body weight change, disease activity index (DAI) and intestinal histology were used for the determination of the anti-inflammatory effects of DACNs. The gene expression levels of tight junction-related proteins in the intestine, myeloperoxidase activity, inducible nitric oxide synthase activity in colonic tissues and pro-inflammatory cytokine production in serum were also measured to elucidate the mechanism of DACN action. Eighty micrograms of DACNs per kilogram of body weight produced potent anti-inflammatory effects in the mouse model of inflammatory bowel disease (IBD), as shown by the DAI (2.78 ± 0.38 vs. 0.44 ± 0.51). Therefore, DACNs may be applied as a potential food supplement in IBD therapy.

Graphical abstract: Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model

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Publication details

The article was received on 29 Aug 2016, accepted on 04 Jan 2017 and first published on 06 Jan 2017


Article type: Paper
DOI: 10.1039/C6FO01273F
Food Funct., 2017,8, 659-669

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    Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model

    T. Chen, S. Hu, H. Zhang, Q. Guan, Y. Yang and X. Wang, Food Funct., 2017, 8, 659
    DOI: 10.1039/C6FO01273F

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