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Issue 49, 2017
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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

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Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Graphical abstract: A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

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Publication details

The article was received on 08 May 2017, accepted on 25 May 2017 and first published on 25 May 2017


Article type: Communication
DOI: 10.1039/C7CC03584E
Chem. Commun., 2017,53, 6649-6652

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    A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

    Y. Hwang, C. W. Coley, M. Abolhasani, A. L. Marzinzik, G. Koch, C. Spanka, H. Lehmann and K. F. Jensen, Chem. Commun., 2017, 53, 6649
    DOI: 10.1039/C7CC03584E

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