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Issue 48, 2016
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Core–shell alginate@silica microparticles encapsulating probiotics

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Abstract

Lactobacillus rhamnosus GG (LGG) was encapsulated in core–shell alginate–silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics.

Graphical abstract: Core–shell alginate@silica microparticles encapsulating probiotics

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Supplementary files

Article information


Submitted
26 Oct 2016
Accepted
17 Nov 2016
First published
17 Nov 2016

J. Mater. Chem. B, 2016,4, 7929-7935
Article type
Paper

Core–shell alginate@silica microparticles encapsulating probiotics

F. B. Haffner, M. Girardon, S. Fontanay, N. Canilho, R. E. Duval, M. Mierzwa, M. Etienne, R. Diab and A. Pasc, J. Mater. Chem. B, 2016, 4, 7929 DOI: 10.1039/C6TB02802K

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