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Issue 39, 2016
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Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

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Abstract

A novel bioactive composite based on wheat protein (WP) and mesoporous magnesium silicate (m-MS) with a high specific surface area is presented in this study for potential bone tissue regeneration. Wheat protein (WP) is a type of a biodegradable natural polymer material. The m-MS was prepared by the sol–gel technique, which was incorporated into WP to fabricate m-MS/WP composites. The increasing amount of m-MS improved the surface hydrophilicity of m-MS/WP composites. The results showed that the degradation ratio of the m-MS/WP composites increased with an increase in the m-MS content after it was soaked in a Tris–HCl solution for 12 weeks. Moreover, the m-MS/WP composites with 40 wt% m-MS content (WP40) were able to maintain a suitable pH value over a prolonged soaking time, which might be dependent on the content of the m-MS. The WP40 showed a good apatite formation ability after it was soaked in simulated body fluid (SBF) for 7 days, indicating good bioactivity. Moreover, the WP40 with cytocompatibility stimulated the attachment, proliferation and differentiation of MC3T3-E1 osteoblast cells. Briefly, the results indicated that WP40 had good bioactivity, degradability, cytocompatibility and osteogenesis and might be a new biomaterial for bone regeneration.

Graphical abstract: Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

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Article information


Submitted
12 Jun 2016
Accepted
09 Sep 2016
First published
09 Sep 2016

J. Mater. Chem. B, 2016,4, 6428-6436
Article type
Paper

Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

S. Feng, J. Li, X. Jiang, X. Li, Y. Pan, L. Zhao, A. R. Boccaccini, K. Zheng, L. Yang and J. Wei, J. Mater. Chem. B, 2016, 4, 6428
DOI: 10.1039/C6TB01449F

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