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Issue 28, 2016
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Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

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Abstract

Integrated theranostic nanosystems that combine therapeutic methods with suitable medical imaging modality are highly needed in the improvement of cancer theranostic approaches. Herein, polydopamine (PDA)-shelled NaYF4:Yb,Er@NaYF4:Yb nanoparticles (UCNPs) capable of loading indocyanine green (ICG) molecules via electrostatic adsorption, hydrophobic interaction and π–π stacking were successfully designed and synthesized (UCNPs@PDA-ICG, denoted as UPI) for upconversion imaging and combined photothermal/photodynamic therapy (PTT/PDT) with enhanced antitumor efficacy. We have found that ICG in this novel anticancer nanoplatform can be triggered impressively by 808-nm irradiation to produce both a photothermal effect and cytotoxic reactive oxygen species (ROS), thus achieving a good PTT/PDT synergistic effect. Notably, compared with free ICG molecules, UPI nanocomposites show much higher photostability and thermal stability. Both in vitro and in vivo experiments show that the as-obtained UPI can ablate cancer cells effectively with 808-nm irradiation, revealing their great potential as a NIR-mediated dual-modal therapeutic platform. Meanwhile, the core of UCNPs can be used for UCL imaging. All these results demonstrate great potentiality of UPI as a novel type of theranostic agent for the treatment of tumors.

Graphical abstract: Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

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Supplementary files

Article information


Submitted
31 Mar 2016
Accepted
14 Jun 2016
First published
21 Jun 2016

J. Mater. Chem. B, 2016,4, 4884-4894
Article type
Paper

Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

B. Liu, C. Li, B. Xing, P. Yang and J. Lin, J. Mater. Chem. B, 2016, 4, 4884
DOI: 10.1039/C6TB00799F

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