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Issue 6, 2016
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Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

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Abstract

We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleration of the release rate of an entrapped model drug.

Graphical abstract: Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

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Publication details

The article was received on 26 Sep 2015, accepted on 11 Jan 2016 and first published on 12 Jan 2016


Article type: Communication
DOI: 10.1039/C5TB02004B
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Citation: J. Mater. Chem. B, 2016,4, 1035-1039
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    Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

    E. M. Nehls, A. M. Rosales and K. S. Anseth, J. Mater. Chem. B, 2016, 4, 1035
    DOI: 10.1039/C5TB02004B

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