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Issue 105, 2016
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Preparation of pH-responsive hollow poly(MAA-co-EGDMA) nanocapsules for drug delivery and ultrasound imaging

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Abstract

pH-Responsive hollow poly(MAA-co-EGDMA) (abbreviated as HPMAA) copolymer nanocapsules with uniform core size of ∼250 nm and flexible shell thickness of ∼17 nm were synthesized by a hard-template protocol that combined a sol–gel process and surface-initialized polymerization. The silica template was then removed in a 10% HF solution. After further partial surface modification the HPMAA with biocompatible methoxypolyethylene glycol amine (mPEG2000-NH2) and the HPMAA–mPEG nanocapsules displayed negligible hemolytic activity and low cytotoxicity that could be used for pH-responsive delivery of drug (doxorubicin: DOX) and ultrasound imaging. The HPMAA–mPEG nanocapsules have high DOX-loading content (52.4 wt%). The DOX-loaded nanocapsules can be efficiently internalized by cells and controlled release within 20 h under high pH (7.4) condition, resulting substantial inhibition of HeLa cells. Then, the real-time in vivo ultrasound imaging of mice demonstrated that the HPMAA–mPEG nanocapsules can also be used as a novel ultrasound imaging contrast agent.

Graphical abstract: Preparation of pH-responsive hollow poly(MAA-co-EGDMA) nanocapsules for drug delivery and ultrasound imaging

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Publication details

The article was received on 26 Aug 2016, accepted on 25 Oct 2016 and first published on 27 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA21411H
Citation: RSC Adv., 2016,6, 103754-103762
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    Preparation of pH-responsive hollow poly(MAA-co-EGDMA) nanocapsules for drug delivery and ultrasound imaging

    H. Hu, X. Zhang, J. Sun, L. An, J. Du, H. Yang, F. Li, H. Wu and S. Yang, RSC Adv., 2016, 6, 103754
    DOI: 10.1039/C6RA21411H

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