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Issue 102, 2016, Issue in Progress
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New route to 1,4-oxazepane and 1,4-diazepane derivatives: synthesis from N-propargylamines

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Abstract

N-Propargylamines are one of the most useful and versatile building blocks in organic synthesis that are successfully transformed into many significant N-heterocycles. Due to high atom economy and shorter synthetic routes, the synthesis of 1,4-oxazepane and 1,4-diazepane cores from N-propargylamines have undergone an explosive growth in recent years. This review gives an overview of new developments in the synthesis of the title compounds from N-propargylamines in recent years. Mechanistic aspects of the reactions are considered and discussed in detail.

Graphical abstract: New route to 1,4-oxazepane and 1,4-diazepane derivatives: synthesis from N-propargylamines

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Article information


Submitted
17 Aug 2016
Accepted
10 Oct 2016
First published
11 Oct 2016

RSC Adv., 2016,6, 99781-99793
Article type
Review Article

New route to 1,4-oxazepane and 1,4-diazepane derivatives: synthesis from N-propargylamines

E. Vessally, A. Hosseinian, L. Edjlali, A. Bekhradnia and M. D. Esrafili, RSC Adv., 2016, 6, 99781
DOI: 10.1039/C6RA20718A

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