Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 76, 2016, Issue in Progress
Previous Article Next Article

pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity

Author affiliations

Abstract

A facile pH-assisted method for synthesizing curcumin-functionalized selenium nanoparticles (SeNPs@Cur) with enhanced cancer chemopreventive activity is proposed in the present work. It is intriguing to observe that by controlling the pH value of the synthetic reaction system, water-insoluble Cur is successfully decorated on the surfaces of SeNPs@Cur through physical adsorption and the possible formation of Se–O bonds. Moreover, the as-prepared nanocomposites possess high drug conjugation efficiency (5.5%), good chemical stability and more uniform sizes and morphologies in comparison with bare SeNPs. Meanwhile, enhanced chemopreventive activity of SeNPs@Cur is demonstrated through the improvements of their free radical scavenging activities and the increases of their cytotoxicities against cancer cells. Cur surface decoration also increases cellular uptake of elemental Se and apoptosis in HepG2 cells. Studies on underlying mechanisms suggest that SeNPs@Cur-induced apoptosis is dependent on the activation of caspases and the overproduction of intracellular ROS. In conclusion, data herein indicate that the strategy to assemble antioxidant ligands on the surface of SeNPs is a potential way to design novel chemopreventive agents with better safety, tolerability and efficacy profiles.

Graphical abstract: pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity

Back to tab navigation

Supplementary files

Article information


Submitted
23 May 2016
Accepted
22 Jul 2016
First published
25 Jul 2016

RSC Adv., 2016,6, 72213-72223
Article type
Paper

pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity

S. Yu, Y. Wang, W. Zhang, Y. Zhang, W. Zhu, Y. Liu, D. Zhang and J. Wang, RSC Adv., 2016, 6, 72213
DOI: 10.1039/C6RA13291J

Social activity

Search articles by author

Spotlight

Advertisements