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Issue 16, 2016
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Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

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Abstract

7-Methylguanosine (m7G) nucleotides labelled with acetylpyrene (AcPy) were synthesized as fluorescent mRNA 5′ end (cap) analogues. The unique fluorescent properties of m7G–AcPy conjugates, different from G–AcPy, can be applied to studying various mRNA cap-related processes including the evaluation of putative inhibitors of DcpS enzyme—a therapeutic target in neuromuscular diseases.

Graphical abstract: Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

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Publication details

The article was received on 23 Feb 2016, accepted on 08 Mar 2016 and first published on 08 Mar 2016


Article type: Communication
DOI: 10.1039/C6OB00419A
Org. Biomol. Chem., 2016,14, 3863-3868

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    Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

    R. Kasprzyk, J. Kowalska, Z. Wieczorek, M. Szabelski, R. Stolarski and J. Jemielity, Org. Biomol. Chem., 2016, 14, 3863
    DOI: 10.1039/C6OB00419A

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