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Issue 18, 2016
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High-throughput acoustic separation of platelets from whole blood

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Abstract

Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL min−1 throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal and platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.

Graphical abstract: High-throughput acoustic separation of platelets from whole blood

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Article information


Submitted
25 May 2016
Accepted
22 Jul 2016
First published
01 Aug 2016

Lab Chip, 2016,16, 3466-3472
Article type
Paper
Author version available

High-throughput acoustic separation of platelets from whole blood

Y. Chen, M. Wu, L. Ren, J. Liu, P. H. Whitley, L. Wang and T. J. Huang, Lab Chip, 2016, 16, 3466
DOI: 10.1039/C6LC00682E

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