Jump to main content
Jump to site search

Issue 13, 2016
Previous Article Next Article

Turning the corner in fertility: high DNA integrity of boundary-following sperm

Author affiliations

Abstract

We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

Graphical abstract: Turning the corner in fertility: high DNA integrity of boundary-following sperm

Back to tab navigation

Supplementary files

Article information


Submitted
12 Apr 2016
Accepted
23 May 2016
First published
23 May 2016

Lab Chip, 2016,16, 2418-2422
Article type
Communication

Turning the corner in fertility: high DNA integrity of boundary-following sperm

L. Eamer, M. Vollmer, R. Nosrati, M. C. San Gabriel, K. Zeidan, A. Zini and D. Sinton, Lab Chip, 2016, 16, 2418
DOI: 10.1039/C6LC00490C

Social activity

Search articles by author

Spotlight

Advertisements