Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 10, 2016
Previous Article Next Article

Laminarin favorably modulates gut microbiota in mice fed a high-fat diet

Author affiliations


We investigated the anti-obesity effects of the potential prebiotic, laminarin, on mice fed a high-fat diet. A metagenomics approach was applied to characterize the ecological and functional differences of gut microbiota among mice fed a normal diet (CTL), a high-fat diet (HFD), and a laminarin-supplemented high-fat diet (HFL). The HFL mice showed a slower weight gain than the HFD mice during the laminarin-feeding period, but the rate of weight gain increased after the termination of laminarin supplementation. Gut microbial community analysis showed clear differences between the CTL and HFD mice, whereas the HFL mice were between the two. A higher abundance of carbohydrate active enzymes was observed in the HFL mice compared to the HFD mice, with especially notable increases in glycoside hydrolase and polysaccharide lyases. A significant decrease in Firmicutes and an increase in the Bacteroidetes phylum, especially the genus Bacteroides, were observed during laminarin ingestion. Laminarin ingestion altered the gut microbiota at the species level, which was re-shifted after termination of laminarin ingestion. Therefore, supplementing laminarin could reduce the adverse effects of a high-fat diet by shifting the gut microbiota towards a higher energy metabolism. Thus, laminarin could be used to develop anti-obesity functional foods. Our results also suggest that laminarin would need to be consumed regularly in order to prevent or manage obesity.

Graphical abstract: Laminarin favorably modulates gut microbiota in mice fed a high-fat diet

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2016, accepted on 23 Aug 2016 and first published on 25 Aug 2016

Article type: Paper
DOI: 10.1039/C6FO00929H
Food Funct., 2016,7, 4193-4201

  •   Request permissions

    Laminarin favorably modulates gut microbiota in mice fed a high-fat diet

    S. G. Nguyen, J. Kim, R. B. Guevarra, J. Lee, E. Kim, S. Kim and T. Unno, Food Funct., 2016, 7, 4193
    DOI: 10.1039/C6FO00929H

Search articles by author