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Issue 28, 2015
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DNA interaction, cytotoxicity, antibacterial and antituberculosis activity of oxovanadium(iv) complexes derived from fluoroquinolones and 4-hydroxy-5-((4-hydroxyphenyl)diazenyl)thiazole-2(3H)-thione

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Abstract

Oxovanadium complexes (5a–5g) with fluoroquinolone ligands and azodye rhodanine (4-hydroxy-5-((4-hydroxyphenyl)diazenyl)thiazole-2(3H)-thione) were synthesized and the effect of different groups was studied, which displayed various biological and medicinal activities. The newly formed compounds were characterized using ESI-MS, UV-vis, IR, ESR spectroscopy, elemental analysis and molar electric conductivity. The in vitro antibacterial activity of the complexes against three Gram negative and two Gram positive microorganisms was studied and compared to the activity of free ligand and it shows considerable results. The minimum inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis was determined and among all the complexes, 5c and 5d showed potency. The in vitro cytotoxicity of the complexes was determined with a brine shrimp bioassay and the LD50 obtained is in the range of 4–12 μg mL−1. The DNA binding activity was studied using UV-vis titration and viscosity measurements, and 5c has the highest binding constant value (6.91 × 105 M−1). DNA nuclease activity was studied using the agarose gel electrophoresis method and the compounds show 70–80% cleavage.

Graphical abstract: DNA interaction, cytotoxicity, antibacterial and antituberculosis activity of oxovanadium(iv) complexes derived from fluoroquinolones and 4-hydroxy-5-((4-hydroxyphenyl)diazenyl)thiazole-2(3H)-thione

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Supplementary files

Article information


Submitted
21 Jan 2015
Accepted
06 Feb 2015
First published
25 Feb 2015

RSC Adv., 2015,5, 21710-21719
Article type
Paper
Author version available

DNA interaction, cytotoxicity, antibacterial and antituberculosis activity of oxovanadium(IV) complexes derived from fluoroquinolones and 4-hydroxy-5-((4-hydroxyphenyl)diazenyl)thiazole-2(3H)-thione

S. B. Gajera, J. V. Mehta and M. N. Patel, RSC Adv., 2015, 5, 21710
DOI: 10.1039/C5RA01222H

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