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Issue 29, 2015
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Antiplasmodial activity of short peptide-based compounds

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Abstract

Three series of short peptide-based compounds were synthesized, which upon evaluation against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum in vitro, produced IC50 values ranging between 1.4–4.7 μg mL−1. Importantly, higher antimalarial activity against the drug-resistant strain of P. falciparum (W2) was observed for the tested peptides, indicating their potential in the treatment of drug-resistant malaria parasites. The lack of cytotoxicity in all tested peptides provides evidence of their safety profile. The selected peptides were evaluated in an enzymatic inhibitory assay against plasmepsin II, a potential target for antiplasmodial activity, also indicated from the results of the molecular docking studies.

Graphical abstract: Antiplasmodial activity of short peptide-based compounds

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Publication details

The article was received on 14 Jan 2015, accepted on 12 Feb 2015 and first published on 17 Feb 2015


Article type: Paper
DOI: 10.1039/C5RA00779H
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RSC Adv., 2015,5, 22674-22684

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    Antiplasmodial activity of short peptide-based compounds

    A. Mahindra, R. P. Gangwal, S. Bansal, N. E. Goldfarb, B. M. Dunn, A. T. Sangamwar and R. Jain, RSC Adv., 2015, 5, 22674
    DOI: 10.1039/C5RA00779H

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