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Issue 6, 2015
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Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

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Abstract

A convenient and efficient synthetic method for the construction of morpholine and piperazine derivatives in moderate to good yields was established. The reaction proceeds smoothly with 1.0 mol% gold catalyst loading. A plausible mechanism involving the cascade cyclization and isomerizations to produce the six-membered ring was proposed and supported by deuterium labeling experiments.

Graphical abstract: Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

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Supplementary files

Article information


Submitted
16 Feb 2015
Accepted
10 Apr 2015
First published
20 Apr 2015

Org. Chem. Front., 2015,2, 721-725
Article type
Research Article
Author version available

Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

L. Yao, Y. Wang and K. Huang, Org. Chem. Front., 2015, 2, 721
DOI: 10.1039/C5QO00060B

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