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Issue 3, 2015
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Large area CMOS bio-pixel array for compact high sensitive multiplex biosensing

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Abstract

A novel CMOS bio-pixel array which integrates assay substrate and assay readout is demonstrated for multiplex and multireplicate detection of a triplicate of cytokines with single digit pg ml−1 sensitivities. Uniquely designed large area bio-pixels enable individual assays to be dedicated to and addressed by single pixels. A capability to simultaneously measure a large number of targets is provided by the 128 available pixels. Chemiluminescent assays are carried out directly on the pixel surface which also detects the emitted chemiluminescent photons, facilitating a highly compact sensor and reader format. The high sensitivity of the bio-pixel array is enabled by the high refractive index of silicon based pixels. This in turn generates a strong supercritical angle luminescence response significantly increasing the efficiency of the photon collection over conventional farfield modalities.

Graphical abstract: Large area CMOS bio-pixel array for compact high sensitive multiplex biosensing

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Supplementary files

Article information


Submitted
02 Sep 2014
Accepted
03 Dec 2014
First published
04 Dec 2014

Lab Chip, 2015,15, 877-881
Article type
Paper
Author version available

Large area CMOS bio-pixel array for compact high sensitive multiplex biosensing

L. Sandeau, C. Vuillaume, S. Contié, E. Grinenval, F. Belloni, H. Rigneault, R. M. Owens and M. B. Fournet, Lab Chip, 2015, 15, 877
DOI: 10.1039/C4LC01025F

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