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Issue 51, 2015
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Metabolic remodeling of bacterial surfaces via tetrazine ligations

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Abstract

Bioorthogonal click ligations are extensively used for the introduction of functional groups in biological systems. Tetrazine ligations are attractive in that they are catalyst-free and display favorable kinetics. We describe the efficient remodeling of bacterial cell surfaces using unnatural D-amino acids derivatized with tetrazine ligation handles. The metabolic incorporation of these unnatural D-amino acids onto bacterial cell surfaces resulted in a site-selective installation of fluorophores.

Graphical abstract: Metabolic remodeling of bacterial surfaces via tetrazine ligations

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Supplementary files

Article information


Submitted
25 Feb 2015
Accepted
22 May 2015
First published
22 May 2015

Chem. Commun., 2015,51, 10330-10333
Article type
Communication
Author version available

Metabolic remodeling of bacterial surfaces via tetrazine ligations

S. E. Pidgeon and M. M. Pires, Chem. Commun., 2015, 51, 10330
DOI: 10.1039/C5CC01693B

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