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Issue 87, 2014
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Synthesis of oxazepin-quinoxaline bis-heterocyclic scaffolds via an efficient three component synthetic protocol

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Abstract

An efficient protocol has been developed to access a series of novel highly complex bis-heterocyclic oxazepin-quinoxaline derivatives. The new bifunctional compounds were synthesized via a one-pot three component reaction between 2-(2-formylphenoxy)acetic acid, an amine and 6-hydroxybenzo[f]quinoxaline-2,3-dicarbonitrile in toluene under reflux conditions without using any catalyst in good to excellent yields.

Graphical abstract: Synthesis of oxazepin-quinoxaline bis-heterocyclic scaffolds via an efficient three component synthetic protocol

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Publication details

The article was received on 11 Aug 2014, accepted on 15 Sep 2014 and first published on 15 Sep 2014


Article type: Communication
DOI: 10.1039/C4RA08486A
RSC Adv., 2014,4, 46844-46850

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    Synthesis of oxazepin-quinoxaline bis-heterocyclic scaffolds via an efficient three component synthetic protocol

    F. Hajishaabanha and A. Shaabani, RSC Adv., 2014, 4, 46844
    DOI: 10.1039/C4RA08486A

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