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Issue 4, 2014
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Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations

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Abstract

The aim of this research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that possess self-antioxidative properties, having advantages in terms of minimal side effects and exhibiting the ability to simultaneously co-encapsulate and co-release two active compounds. The focus has been oriented towards developing safe cosmetic formulations with broad-spectrum photoprotection based on these new lipid nanocarriers that contain large amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane – BMDBM and octocrylene – OCT). The lipid nanocarriers have a spherical shape and show good physical stability, with a zeta potential in the range of −25.5 to −32.4 mV. Both vegetable oils play a key role in the preparation of efficient nanocarriers, leading to a less ordered arrangement of the lipid core that offers many spaces for the entrapment of large amounts of BMDBM (79%) and OCT (90%), as wells as improved antioxidant activity and UV absorption properties, particularly for the lipid nanocarriers prepared from rice bran oil. By formulating the lipid nanocarriers into creams containing only 3.5% of the UV filters and 10.5% of the vegetable oils, the resulting sunscreens exhibited improved photoprotection, reflecting up to 91% and 93% of UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarrier. After 24 hours, a slow release of BMDBM (less than 4%) and OCT (17.5%) was obtained through a Fick diffusion process. This study demonstrates a significant advance in the areas of both nanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence of a high content of nanostructured vegetable oils combined with a low amount of synthetic UV filters in the same carrier system.

Graphical abstract: Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations

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Publication details

The article was received on 22 Aug 2013, accepted on 13 Jan 2014 and first published on 14 Jan 2014


Article type: Paper
DOI: 10.1039/C3PP50290B
Photochem. Photobiol. Sci., 2014,13, 703-716

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    Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations

    G. Niculae, I. Lacatusu, N. Badea, R. Stan, B. S. Vasile and A. Meghea, Photochem. Photobiol. Sci., 2014, 13, 703
    DOI: 10.1039/C3PP50290B

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