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Issue 18, 2014
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How DNA is damaged by external electric fields: selective mutation vs. random degradation

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Abstract

DNA is constantly exposed to exogenous agents that randomly damage the genetic code. However, external perturbations might also be used to induce malignant cell death if the mutation processes are controlled. The present communication reports a set of parameters allowing DNA mutation through the use of intense external electric fields. This is a step towards the design of pulsed electric field therapy for genetic diseases.

Graphical abstract: How DNA is damaged by external electric fields: selective mutation vs. random degradation

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Supplementary files

Article information


Submitted
25 Oct 2013
Accepted
19 Nov 2013
First published
25 Nov 2013

Phys. Chem. Chem. Phys., 2014,16, 8243-8246
Article type
Communication

How DNA is damaged by external electric fields: selective mutation vs. random degradation

J. P. Cerón-Carrasco, J. Cerezo and D. Jacquemin, Phys. Chem. Chem. Phys., 2014, 16, 8243
DOI: 10.1039/C3CP54518K

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