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Issue 99, 2014
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TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction

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Abstract

A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C–H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.

Graphical abstract: TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction

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Supplementary files

Article information


Submitted
28 Aug 2014
Accepted
28 Oct 2014
First published
28 Oct 2014

Chem. Commun., 2014,50, 15780-15783
Article type
Communication
Author version available

TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction

J. Hu, H. Qin, W. Xu, J. Li, F. Zhang and H. Zheng, Chem. Commun., 2014, 50, 15780
DOI: 10.1039/C4CC06653G

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