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Issue 40, 2014
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68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

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Abstract

We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Graphical abstract: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

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Supplementary files

Article information


Submitted
16 Dec 2013
Accepted
19 Feb 2014
First published
21 Feb 2014

Chem. Commun., 2014,50, 5215-5217
Article type
Communication
Author version available

68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

B. Nichols, Z. Qin, J. Yang, D. R. Vera and N. K. Devaraj, Chem. Commun., 2014, 50, 5215
DOI: 10.1039/C3CC49530B

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