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Issue 12, 2013
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Flavans from Desmos cochinchinensis as potent aromatase inhibitors

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Abstract

Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory activity through binding, as revealed by molecular docking studies, with aromatase at Arg115, Met374, and Leu477; the C-7 hydroxyl (or methoxyl) forms hydrogen bonds with Met374 and Arg115 of aromatase.

Graphical abstract: Flavans from Desmos cochinchinensis as potent aromatase inhibitors

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Publication details

The article was received on 13 Jun 2013, accepted on 21 Sep 2013 and first published on 24 Sep 2013


Article type: Concise Article
DOI: 10.1039/C3MD00166K
Citation: Med. Chem. Commun., 2013,4, 1590-1596

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    Flavans from Desmos cochinchinensis as potent aromatase inhibitors

    V. Prachyawarakorn, S. Sangpetsiripan, P. Surawatanawong, C. Mahidol, S. Ruchirawat and P. Kittakoop, Med. Chem. Commun., 2013, 4, 1590
    DOI: 10.1039/C3MD00166K

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