Jump to main content
Jump to site search

Issue 33, 2013
Previous Article Next Article

Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis

Author affiliations

Abstract

Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin)2EtOH]2 (VOchrys) on the MG-63 human osteosarcoma cell line. Oxovanadium(IV), chrysin and VOchrys caused a concentration-dependent inhibition of cell viability. The complex was the strongest antiproliferative agent (p < 0.05). Cytotoxicity and genotoxicity studies also showed a concentration effect. Reactive oxygen species (ROS) and the alterations in the GSH/GSSG ratio underlie the main mechanisms of action of VOchrys. Additions of ROS scavengers (vitamin C plus vitamin E) or GSH to the viability experiments demonstrated beneficial effects (p < 0.01). Besides, the complex triggered apoptosis, disruption of the mitochondria membrane potential (MMP), increased levels of caspase 3 and DNA fragmentation measured by the sub-G1 peak in cell cycle arrest experiments (p < 0.01). Collectively, VOchrys is a cell death modulator and a promissory complex to be used in cancer treatments.

Graphical abstract: Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis

Back to tab navigation

Supplementary files

Article information


Submitted
26 Feb 2013
Accepted
21 May 2013
First published
21 May 2013

Dalton Trans., 2013,42, 11868-11880
Article type
Paper

Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis

I. E. Leon, A. L. Di Virgilio, V. Porro, C. I. Muglia, L. G. Naso, P. A. M. Williams, M. Bollati-Fogolin and S. B. Etcheverry, Dalton Trans., 2013, 42, 11868
DOI: 10.1039/C3DT50524C

Social activity

Search articles by author

Spotlight

Advertisements