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Issue 11, 2012
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Heteroaromatic donors in donor–acceptor–donor based fluorophores facilitate zinc ion sensing and cell imaging

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Abstract

The excited state intra molecular charge transfer (ICT) property of fluorophores has been extensively used for the design of fluorescent chemosensors. Herein, we report the synthesis and properties of three donor–π-acceptor–π-donor (D–π-A–π-D) based molecular probes BP, BT and BA. Two heteroaromatic rings, pyrrole (BP), and thiophene (BT) and a non-heteroaromatic ring N-alkoxy aniline (BA) were selected as donor moieties which were linked to a bipyridine binding site through a vinylic linkage. The heteroaromatic systems BP and BT perform selective and ratiometric emission signalling for zinc ions whereas the non-heteroaromatic probe BA does not. The advantages of the D–π-A–π-D design strategy in the design of ICT based probes for the selective fluorescent ratiometric signalling of zinc ions in biological media is discussed. Further, the use of BP, BT and BA for imaging Zn2+ ions from MCF-7 cell lines is demonstrated.

Graphical abstract: Heteroaromatic donors in donor–acceptor–donor based fluorophores facilitate zinc ion sensing and cell imaging

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Publication details

The article was received on 17 Apr 2012, accepted on 09 Jul 2012 and first published on 10 Jul 2012


Article type: Paper
DOI: 10.1039/C2PP25110H
Photochem. Photobiol. Sci., 2012,11, 1715-1723

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    Heteroaromatic donors in donor–acceptor–donor based fluorophores facilitate zinc ion sensing and cell imaging

    S. Sreejith, K. P. Divya, P. Jayamurthy, J. Mathew, V. N. Anupama, D. S. Philips, P. Anees and A. Ajayaghosh, Photochem. Photobiol. Sci., 2012, 11, 1715
    DOI: 10.1039/C2PP25110H

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