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Issue 10, 2009
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Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium†

Shikai Yan,‡b   Bin Wu,‡c   Zhongying Lin,a   Huizi Jin,b   Jianhua Huang,c   Yun Yang,b   Xinmin Zhang,c   Ziyin Shen*c  and  Weidong Zhang*ab  
Author affiliations

* Corresponding authors

a School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China
E-mail: wdzhangy@hotmail.com
Fax: +86 21-81871244
Tel: +86 21-81871244

b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, P. R. China

c Institute of Integrative Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200424, P. R. China
E-mail: ziyinshen@126.com
Fax: +86 21-62490934
Tel: +86 21-62490934

Abstract

A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling’s T2 control chart, among which 25 metabolites were structurally identified by MSn analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation.

Graphical abstract: Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

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Article information

https://doi.org/10.1039/B816407J
Submitted
18 Sep 2008
Accepted
05 Jun 2009
First published
14 Jul 2009
Mol. BioSyst., 2009,5, 1204-1213
Article type
Paper
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Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

S. Yan, B. Wu, Z. Lin, H. Jin, J. Huang, Y. Yang, X. Zhang, Z. Shen and W. Zhang, Mol. BioSyst., 2009, 5, 1204
DOI: 10.1039/B816407J

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